Installing NONMEM

MacOS

This instruction works with macOS13 (Ventura) and later versions. Not all steps are necessary depending on your Mac’s existing configuration. All commands can be executed in terminal, such as Terminal.app, Mac’s built-in terminal, and VSCode.

Install XCode Command Line Tools

xcode-select --install

Install and configure GCC

GCC is a collections of tools required to install NONMEM. NONMEM is only compatible with GCC version 11 or earlier.

To install GCC Ver.11, we need to install Homebrew first, which is a package management tool for MacOS and Linux. Run the command in the terminal:

/bin/bash -c "$(curl -fsSL https://raw.githubusercontent.com/Homebrew/install/HEAD/install.sh)"

Once Homebrew is installed. Run this command to install GCC Ver.11:

brew install gcc@11

GCC@11 installs gcc-11 and gfortran-11 commands, which are necessary to compile NONMEM source files. However, NONMEM only recognize gcc and gfortran commands. You can use either methods below to resolve this issue:

Method 1: Symlink

We can create symbolic links to make gcc and gfortran point to gcc-11 and gcc-fortran using the following commands:

sudo ln -s $(which gcc-11) /usr/local/bin/gcc
sudo ln -s $(which gfortran-11) /usr/local/bin/gfortran

Run this command to verify the symbolic links:

which gcc
which gfortran

The following messages should return:

/usr/local/bin/gcc
/usr/local/bin/gfortran

Method 2: Alias

We can set gcc and gfortran as aliases for gcc-11 and gfortran-11 using the following commands:

echo 'alias gcc="gcc-11"' >> ~/.zprofile
echo 'alias gfortran="gfortran-11"' >> ~/.zprofile

Reload shell configuration for alias to take effect:

source ~/.zprofile

Verify the configuration:

which gcc
which gfortran

These messages should show up:

gcc: aliased to gcc-11
gfortran: aliased to gfortran-11

Disable MacOS Gatekeeper

If MacOS flagged NONMEM as an application from an unverified developer and triggered Gatekeeper security preventing installation. We can temporarily disable Gatekeeper:

sudo spctl --global-disable

Install NONMEM

Assuming the NONMEM source file folder is located at ~/Downloads/NM751CD, and the target installation location is /opt/nm751.

We first navigate to the NONMEM source directory:

cd ~/Downloads/NM751CD 

Run the command below to initiate the NONMEM installation:

sudo /bin/bash ./SETUP75 ~/Downloads/NM751CD /opt/nm751 gfortran

You will be prompted to enter your password, after which you can follow the installation wizard to complete the process.

Finally, after the installation is complete, remember to re-enable Gatekeeper:

sudo spctl --global-enable

*As of Dec 2024, the following configurations have been successfully tested.

Device	macOS	GCC	NONMEM
Macbook Pro (M1, 2020)	Big Sur	10.2 x86	7.5.1
Macbook Pro (M1, 2020)	Monterey	11.3 ARM	7.5.1
Macbook Pro (M1, 2020)	Ventura	11.5 ARM	7.5.1
Macbook Pro (M3 Pro, 2023)	Sonoma	11.3 x86	7.5.1
Macbook Pro (M3 Pro, 2023)	Sequoia	11.5 ARM	7.5.1
Macbook Pro (M4 Pro, 2024)	Sequoia	11.5 ARM	7.6.0

Windows

NONMEM allows one-click installations for Windows environment. You can find the file on NONMEM’s official page https://nonmem.iconplc.com/#/nonmem751 by copying and pasting the link to your browser. The file name should be similar in format to NONMEM751_64gfortran463.exe.

Additional documents can be found in “Additional Documents” in dropdown menu